Craig Mayer, Nick WIlliams, Vojtech Huser
Lister Hill National Center for Biomedical Communications, National Library of Medicine, NIH, Bethesda, MD

See the full regCTG repository at https://github.com/lhncbc/CRI/tree/master/regCTG

To return to the list of conditions and view other reports go to https://lhncbc.github.io/CRI/regCTG/regCTG-condition_report_links.html

Study Counts

Type Study_count
Total_Studies 161
interventional 108
Observational 49
Registry 4

Studies over Time by Start Date

```

Interventional Trials

Intervention Type

intervention_type Study_Count
Drug 43
Drug|placebo 29
Behavioral 13
Device 8
Other 6
Biological|placebo 2
Biological 1
Device|Other 1
Device|placebo 1
Diagnostic Test 1
Dietary Supplement|Drug 1
Dietary Supplement|Drug|Other 1
Dietary Supplement|placebo 1

Count of Studies by Intervention (normalized and mapped)

Interventions over Time

Yearly studies for each intervention by start date

Studies by Country

Country Study_Count
United States 28
Korea, Republic of 12
NA 10
Canada 8
Spain 6
China 3
Denmark 3
Finland 3
Germany 3
Netherlands 3
France 2
Japan| 2
Switzerland 2
Austria|Chile 1
Austria|Germany 1
Belgium 1
Brazil 1
Bulgaria|Germany|Hungary|Ukraine 1
Canada|Netherlands|United Kingdom 1
China|Malaysia|Philippines|Singapore|Taiwan|Thailand 1
Germany|Andorra|Argentina|Australia|Belgium|Brazil|Canada|Chile|China|Colombia|Croatia|Czech Republic|France|Greece|Hong Kong|Indonesia|Ireland|Italy|Latvia|Lithuania|Mexico|Netherlands|Pakistan|Peru|Philippines|Portugal|South Africa|Spain|Switzerland|Thailand|United Kingdom 1
Germany|Poland 1
Iran, Islamic Republic of 1
Italy 1
Japan 1
Kazakhstan 1
Malaysia 1
Netherlands|United Kingdom 1
Russian Federation 1
Turkey 1
United Kingdom 1
United States|Andorra|Argentina|Brazil|Chile|France|Germany|Greece|Ireland|Israel|Italy|Mexico|South Africa|Spain|United Kingdom 1
United States|Belgium|France|Hungary|Morocco|Spain|Tunisia|Turkey 1
United States|Brazil|Canada|Costa Rica|Germany|India|Lithuania|Mexico|Netherlands|Russian Federation|Spain|United Kingdom|Venezuela 1
United States|Canada|Puerto Rico 1
United States|Germany 1

Sites per Study

Site_count Study_Count
1 68
2 10
3 2
4 1
5 2
6 4
7 1
8 4
12 1
13 1
19 1
20 1
28 2
31 1
32 1
34 1
60 1
65 1
75 1
78 1
90 1
146 1
221 1

Phase

Phase Study_Count
N/A 30
Phase 3 27
Phase 4 25
Phase 2 17
Phase 2/Phase 3 4
Phase 1 2
Phase 1/Phase 2 2
Early Phase 1 1

Number of Arms

Number_of_Arms Count_of_Studies
1 15
2 54
3 10
4 6
5 1
8 1
NA 21

Enrollment Metrics by Phase

Measure Early.Phase.1 N.A Phase.1 Phase.1.Phase.2 Phase.2 Phase.2.Phase.3 Phase.3 Phase.4
Min. 5 12.0000 30.0 17.00 10.0000 10.00 19.0000 1.00
1st Qu. 5 30.5000 43.5 21.75 48.0000 10.75 202.0000 40.00
Median 5 92.0000 57.0 26.50 108.0000 17.00 265.0000 106.00
Mean 5 233.0333 57.0 26.50 114.2941 102.75 469.7037 469.52
3rd Qu. 5 192.5000 70.5 31.25 150.0000 109.00 486.0000 405.00
Max. 5 2000.0000 84.0 36.00 400.0000 367.00 3200.0000 5660.00

Trial Group Type

group_type Group_Count
Experimental 87
Active Comparator 58
Placebo Comparator 30
NA 21
No Intervention 7
Other 6
Sham Comparator 2

Intervention Model

intervention_model Study_Count
Parallel Assignment 78
Single Group Assignment 19
Crossover Assignment 10
Factorial Assignment 1

Primary Purpose

primary_purpose Study_Count
Treatment 86
Prevention 6
Supportive Care 4
Device Feasibility 2
Diagnostic 2
Health Services Research 2
Other 2
NA 2
Basic Science 1
Educational/Counseling/Training 1

Observational Studies

Studies by Country

Country Study_Count
United States 16
United Kingdom 9
NA 7
Germany 2
Peru 2
Sweden 2
Albania|Bosnia and Herzegovina|Kazakhstan|Macedonia, The Former Yugoslav Republic of|Moldova, Republic of|Russian Federation|Slovakia|Ukraine 1
Austria|Brazil|China|Colombia|Croatia|Egypt|El Salvador|Germany|Hong Kong|Hungary|Indonesia|Korea, Republic of|Malaysia|Mexico|Morocco|Netherlands|Pakistan|Philippines|Poland|Singapore|Slovenia|Switzerland|Taiwan|Turkey 1
China 1
Czech Republic 1
Denmark 1
Israel|United Kingdom 1
Pakistan 1
Singapore 1
Slovakia 1
Ukraine 1
United States|Canada 1

Sites per Study

Site_count Study_Count
1 31
2 4
3 1
4 2
6 1
8 1
12 1
21 1
24 1
25 1
28 1
47 1
126 1
135 1
158 1

Enrollment Metrics

Measure Observational
Min 10.00
1st Qu 95.00
Median 349.00
Mean 12774.80
3rd Qu 1337.25
Max 239306.00

Observation Model

observational_model Study_Count
Cohort 22
NA 9
Case-Control 5
Case-Only 4
Case Control 4
Case-Crossover 1
Defined Population, Natural History 1
Ecologic or Community 1
Family-Based 1
Other 1

Time Perspective

time_perspective Study_Count
Prospective 32
Cross-Sectional 9
NA 5
Retrospective 2
Longitudinal, Prospective 1

Registries

Studies by Country

Country Study_Count
United States 2
Finland 1
Italy 1

Sites per Study

Site_count Study_Count
1 2
2 1
6 1

Enrollment Metrics

Measure Registries
Min 68.0
1st Qu 474.5
Median 1805.0
Mean 19669.5
3rd Qu 21000.0
Max 75000.0

Registry Model

observational_model Study_Count
Cohort 4

Time Perspective

time_perspective Study_Count
Other 2
Prospective 2

Follow-up

target_duration Study_Count
15 Years 1
18 Months 1
2 Months 1
2 Years 1

Overview of Studies

Interventional Trials

#If less then 500 trials

nct_id brief_title link overall_status source primary_completion_date
NCT03369119 Effect of Addition Oral Montelukast to Standard Treatment in Acute Asthma in Hospitalized Preschool Children https://ClinicalTrials.gov/show/NCT03369119 Completed Kecioren Education and Training Hospital 2012-10-31
NCT03309800 A Clinical Trial to Evaluate the Efficacy and Safety of HL301 Versus Placebo in Acute Bronchitis Patients https://ClinicalTrials.gov/show/NCT03309800 Completed Hanlim Pharm. Co., Ltd. 2017-08-17
NCT03251911 VX-770 for the Treatment of Chronic Bronchitis https://ClinicalTrials.gov/show/NCT03251911 Recruiting University of Alabama at Birmingham 2021-01-01
NCT03199976 Efficacy of Intermittent Tiotropium in Early Childhood Wheezing https://ClinicalTrials.gov/show/NCT03199976 Active, not recruiting Helsinki University Central Hospital 2020-12-31
NCT03123692 NBMI - Clinical Study on COPD https://ClinicalTrials.gov/show/NCT03123692 Completed EmeraMed 2018-05-30
NCT03107494 Gala FIH Feasibility Study for the Treatment of Chronic Bronchitis https://ClinicalTrials.gov/show/NCT03107494 Active, not recruiting Gala Therapeutics, Inc. 2020-03-30
NCT03085485 The Topic Trial - Study to Determine the Safety and Efficacy of Ivacaftor https://ClinicalTrials.gov/show/NCT03085485 Recruiting University of Alabama at Birmingham 2020-04-30
NCT03073798 The Effectiveness of Roflumilast in Improving Mucociliary Clearance in Patients With COPD and Chronic Bronchitis https://ClinicalTrials.gov/show/NCT03073798 Completed Johns Hopkins University 2015-05-14
NCT02937857 An Add-on Study to Evaluate the Efficacy and Safety of Xiyanping Injection in Pediatric Bronchitis Patients. https://ClinicalTrials.gov/show/NCT02937857 Recruiting Jiangxi Qingfeng Pharmaceutical Co. Ltd. 2020-04-30
NCT02858193 Single Dose, Two-stage Bioequivalence Study of SCMC-Lys Salt 1.35 g Powder vs SCMC-Lys Salt 90 mg/mL Syrup https://ClinicalTrials.gov/show/NCT02858193 Completed Dompé Farmaceutici S.p.A 2016-07-25
NCT02792946 Compare the Efficacy and Safety of Surfolase CR Tablet With Surfolase Capsule in Patients With Acute Bronchitis https://ClinicalTrials.gov/show/NCT02792946 Completed Hyundai Pharmaceutical Co., LTD. 2016-01-31
NCT02637310 Evaluate the Efficacy and Safety of N02RS1 in Patient With Acute Bronchitis https://ClinicalTrials.gov/show/NCT02637310 Completed PharmaKing 2016-03-31
NCT02559791 Anti-Interleukin-5 (IL5) Monoclonal Antibody (MAb) in Prednisone-dependent Eosinophilic Asthma https://ClinicalTrials.gov/show/NCT02559791 Completed McMaster University 2017-04-30
NCT02515799 Mucolytic Effectiveness of Tacholiquine ® in Chronic Bronchitis https://ClinicalTrials.gov/show/NCT02515799 Completed bene-Arzneimittel GmbH 2015-01-31
NCT02483637 Safety and Feasibility Study of Rejuvenairâ„¢ for Treating Chronic Bronchitis Patients https://ClinicalTrials.gov/show/NCT02483637 Active, not recruiting CSA Medical, Inc. 2019-05-31
NCT02250027 A Multicenter, Randomized, Double-blind, Parallel Group Study to Determine the Optimal Dose of HL301 After 7 Days Oral Administration in Acute Bronchitis or Acute Exacerbations of Chronic Bronchitis Patients (HL301: Mixed Extract of Rehmannia Glutinosa, Schisandra and so on) https://ClinicalTrials.gov/show/NCT02250027 Completed Hanlim Pharm. Co., Ltd. 2014-07-31
NCT03385616 Gala Treatment for Chronic Bronchitis in Canada https://ClinicalTrials.gov/show/NCT03385616 Recruiting Gala Therapeutics, Inc. 2019-12-30
NCT02151734 Safety and Efficacy of KALOMINâ„¢ Tab. in Patients With Acute Bronchitis https://ClinicalTrials.gov/show/NCT02151734 Completed Korea United Pharm. Inc. 2013-12-31
NCT02125747 Respiratory Therapy in COPD Exacerbations https://ClinicalTrials.gov/show/NCT02125747 Completed Parc de Salut Mar 2012-05-31
NCT02099799 The Effect of Physical Activity Promotion on Short and Long-term Outcomes in COPD https://ClinicalTrials.gov/show/NCT02099799 Completed VA Office of Research and Development 2019-11-01
NCT02049294 Study of the Steroid Sparing Effect of Xolair (Omalizumab) in Patients With Persistent Eosinophilic Bronchitis https://ClinicalTrials.gov/show/NCT02049294 Completed McMaster University 2017-09-30
NCT02042976 Mindfulness-based Cognitive Therapy for Chronic Obstructive Pulmonary Disease https://ClinicalTrials.gov/show/NCT02042976 Completed University of Aarhus 2016-09-30
NCT02002715 Therapeutic Effect of Different Treatment Course With Inhaled Corticosteroids in Eosinophilic Bronchitis Patients https://ClinicalTrials.gov/show/NCT02002715 Completed The First Affiliated Hospital of Guangzhou Medical University 2018-05-31
NCT01979926 Comparative Evaluate the Efficacy to Acute and Chronic Bronchitis https://ClinicalTrials.gov/show/NCT01979926 Completed PharmaKing 2013-11-30
NCT01958008 BI 113608 Administered as Tablets Twice Daily Over 4 Weeks in Patients With Chronic Obstructive Pulmonary Disease Associated With Chronic Bronchitis https://ClinicalTrials.gov/show/NCT01958008 Completed Boehringer Ingelheim 2014-05-31
NCT01875757 Effect of Supplementation With Vitamin D on the Acute Bronchitis Prevention During the First Year of Life https://ClinicalTrials.gov/show/NCT01875757 Completed Hospital Universitari Vall d’Hebron Research Institute 2016-12-31
NCT01828788 Postoperative Rehabilitation After Cardiac Surgery in Patients at Risk of Respiratory Complications. Effects of a Continuous Bi-laterosternal Infusion of Ropivacaine Through Multihole Catheters https://ClinicalTrials.gov/show/NCT01828788 Completed University Hospital, Clermont-Ferrand 2015-01-19
NCT01800747 Clinical Trial for the Assessment of Delayed Antibiotic Treatment in Pediatric (DAP-Pediatrics) https://ClinicalTrials.gov/show/NCT01800747 Completed Asociacion Colaboracion Cochrane Iberoamericana 2016-06-07
NCT01792271 Sustained Effects of Hypertonic Saline on Mucociliary Clearance in Subjects With Chronic Bronchitis https://ClinicalTrials.gov/show/NCT01792271 Completed University of North Carolina, Chapel Hill 2016-05-31
NCT01734811 Efficacy and Safety Evaluation in Recurrent Wheezing Attacks https://ClinicalTrials.gov/show/NCT01734811 Completed Inmunotek S.L. 2016-05-31
NCT01719822 Physical Activity Augmentation Using Pedometers During Pulmonary Rehabilitation in Chronic Obstructive Pulmonary Disease https://ClinicalTrials.gov/show/NCT01719822 Completed Royal Brompton & Harefield NHS Foundation Trust 2015-02-28
NCT01495780 eRT Remote Health Monitoring https://ClinicalTrials.gov/show/NCT01495780 Completed University of California, Los Angeles 2014-08-20
NCT01467297 Ceftidoren Versus Levofloxacin in the Treatment of Patients With Acute Exacerbations of Chronic Bronchitis (AECB) https://ClinicalTrials.gov/show/NCT01467297 Completed University of Milan 2012-06-30
NCT01463644 Mepolizumab in Chronic Obstructive Pulmonary Diseases (COPD) With Eosinophilic Bronchitis https://ClinicalTrials.gov/show/NCT01463644 Completed McMaster University 2015-08-31
NCT01420445 Safety/Tolerability and Efficacy of YHD001 in Patients With Acute and Chronic Bronchitis https://ClinicalTrials.gov/show/NCT01420445 Completed Yuhan Corporation 2012-05-31
NCT01416480 Clinical Trial to Evaluate the Safety and Efficacy of “Theobromine Capsule” as an Antitussive in Acute Cougher https://ClinicalTrials.gov/show/NCT01416480 Completed Ahn-Gook Pharmaceuticals Co.,Ltd 2011-02-28
NCT01383655 Intravenous Magnesium in Wheezy Bronchitis https://ClinicalTrials.gov/show/NCT01383655 Completed University of Oulu 2016-01-31
NCT01363531 Clinical Trial for the Assessment of Delayed Antibiotic Treatment Strategies https://ClinicalTrials.gov/show/NCT01363531 Completed Fundació Institut de Recerca de l’Hospital de la Santa Creu i Sant Pau 2012-08-31
NCT04415827 Energy Supply in Athletes and Untrained Persons With Bronchopulmonary Diseases https://ClinicalTrials.gov/show/NCT04415827 Recruiting I.M. Sechenov First Moscow State Medical University 2021-12-22
NCT04260555 Clinical Trial to Evaluate the Efficacy and Safety of ‘DW1601’ in Acute Bronchitis https://ClinicalTrials.gov/show/NCT04260555 Active, not recruiting Daewon Pharmaceutical Co., Ltd. 2019-12-09
NCT04252963 Clinical Trial to Assess the Efficacy and Safety of MUCOLASE Tablet(Streptokinase • Streptodornase) https://ClinicalTrials.gov/show/NCT04252963 Recruiting Hanmi Pharmaceutical Company Limited 2021-02-28
NCT04182841 RheOx Registry Study in Europe https://ClinicalTrials.gov/show/NCT04182841 Recruiting Gala Therapeutics, Inc. 2024-12-15
NCT04122495 Treatment of Upper and Lower Respiratory Tract Infections in Young Children Using Probiotic https://ClinicalTrials.gov/show/NCT04122495 Recruiting Universiti Sains Malaysia 2020-08-28
NCT04069312 Roflumilast or Azithromycin to Prevent COPD Exacerbations (RELIANCE) https://ClinicalTrials.gov/show/NCT04069312 Recruiting Johns Hopkins University 2023-02-28
NCT03942926 The Efficacy and Safety of Sirolimus for Plastic Bronchitis https://ClinicalTrials.gov/show/NCT03942926 Recruiting Peking Union Medical College Hospital 2020-05-05
NCT03927365 Muco-ciliary Cleansing of Lungs in COPD With and Without a Salt Particle Inhaler https://ClinicalTrials.gov/show/NCT03927365 Recruiting Liita Care ApS 2020-12-31
NCT03900494 Comparing the Efficacy of Two Valved Holding Chambers in Acute Wheezing https://ClinicalTrials.gov/show/NCT03900494 Recruiting Tampere University 2020-12-31
NCT03892694 Metered Cryospray for the Treatment of Patients With Chronic Obstructive Pulmonary Disease With Chronic Bronchitis https://ClinicalTrials.gov/show/NCT03892694 Recruiting CSA Medical, Inc. 2021-10-31
NCT00129883 Adherence to Guidelines for Antibiotic Use in Respiratory Infections at Hospitals https://ClinicalTrials.gov/show/NCT00129883 Completed Radboud University NA
NCT03827590 Clinical Trials to Assess the Efficacy and Safety of HLIM https://ClinicalTrials.gov/show/NCT03827590 Recruiting SamA Pharmaceutical Co., Ltd 2019-05-30
NCT03738917 Effectiveness of Antitussives, Anticholinergics and Honey Versus Usual Care in Adults With Acute Bronchitis. https://ClinicalTrials.gov/show/NCT03738917 Recruiting Jordi Gol i Gurina Foundation 2020-11-30
NCT03711292 Using Behavioral Science to Reduce Inappropriate Antibiotic Use in Acute Care Settings https://ClinicalTrials.gov/show/NCT03711292 Recruiting Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center 2020-03-31
NCT03657836 The Sublimated Mare Milk Supplement’s Effect on Gut Mucosal Lining After Antibiotics https://ClinicalTrials.gov/show/NCT03657836 Active, not recruiting Nazarbayev University Medical Center 2019-01-20
NCT03654196 A Clinical Trial to Evaluate the Efficacy and Safety of HL301 Versus Umkamin Tab in Acute Bronchitis Patients https://ClinicalTrials.gov/show/NCT03654196 Completed Hanlim Pharm. Co., Ltd. 2018-09-21
NCT03653104 Melodica Orchestra for Dyspnea: Safety and Feasibility Pilot https://ClinicalTrials.gov/show/NCT03653104 Active, not recruiting VA Quality Enhancement Research Intiative 2019-12-31
NCT03631472 Gala Early Feasibility Study of RheOx https://ClinicalTrials.gov/show/NCT03631472 Active, not recruiting Gala Therapeutics, Inc. 2020-08-30
NCT03623282 Study Regarding the Clinical Efficacy of Synatura® in Patients With Chronic Bronchitis Type COPD https://ClinicalTrials.gov/show/NCT03623282 Completed Ahn-Gook Pharmaceuticals Co.,Ltd 2018-05-02
NCT03489837 Phase III Study to Evaluate the Efficacy and Safety of HOB-048 CR Tab. in Comparison With HOB-048 Syrup in Patients With Cough Due to Acute or Chronic Bronchitis https://ClinicalTrials.gov/show/NCT03489837 Completed Hyundai Pharm 2018-10-31
NCT01240174 Demonstration of Near Zero Antibiotic Prescribing for Acute Bronchitis https://ClinicalTrials.gov/show/NCT01240174 Completed Brigham and Women’s Hospital 2014-06-30
NCT01233232 A 4 Week Study to Investigate the Safety and Tolerability of AZD5069 in Patients With Moderate to Severe Chronic Obstructive Pulmonary Disease (COPD) https://ClinicalTrials.gov/show/NCT01233232 Completed AstraZeneca 2011-03-31
NCT01151202 Therapeutic Confirmatory Clinical Trial to Evaluate the Safety and Efficacy of “AG NPP709 Syrup” https://ClinicalTrials.gov/show/NCT01151202 Completed Ahn-Gook Pharmaceuticals Co.,Ltd 2010-05-31
NCT01109160 Study of Azithromycin for Lymphocytic Bronchiolitis/Bronchitis After Lung Transplantation https://ClinicalTrials.gov/show/NCT01109160 Completed KU Leuven 2012-10-31
NCT01077102 Eccentric Exercise Training as Novel Rehabilitation for Chronic Obstructive Pulmonary Disease (COPD) https://ClinicalTrials.gov/show/NCT01077102 Completed McGill University Health Centre/Research Institute of the McGill University Health Centre 2012-12-31
NCT01071161 The Effect of Azithromycin in Patients With Chronic Obstructive Pulmonary Disease (COPD) and Chronic Productive Cough https://ClinicalTrials.gov/show/NCT01071161 Completed Isala 2012-02-29
NCT01033799 Effect of the Consumption of a Fermented Milk on Common Infections in Shift-workers https://ClinicalTrials.gov/show/NCT01033799 Completed Danone Research 2007-04-30
NCT00870896 The Effects of Tiotropium on the Cough Reflex in Patients With Chronic Obstructive Pulmonary Disease (COPD) https://ClinicalTrials.gov/show/NCT00870896 Completed University of South Florida 2009-02-28
NCT04016051 Acceptance of Clarithromycin in a Straw Compared to Syrup in Children With Upper Respiratory Tract Infections https://ClinicalTrials.gov/show/NCT04016051 Completed Grünenthal GmbH 2004-12-23
NCT00720226 Efficacy of Losartan in Preventing Progression of COPD https://ClinicalTrials.gov/show/NCT00720226 Completed Johns Hopkins University 2014-08-31
NCT00683722 PROCHYMALâ„¢ (Human Adult Stem Cells) for the Treatment of Moderate to Severe Chronic Obstructive Pulmonary Disease (COPD) https://ClinicalTrials.gov/show/NCT00683722 Completed Mesoblast, Ltd. 2009-03-09
NCT00680056 Add-on Effects of Tiotropium Over Formoterol in Exercise Tolerance on Chronic Obstructive Pulmonary Disease Patients https://ClinicalTrials.gov/show/NCT00680056 Completed Federal University of São Paulo 2008-12-31
NCT00656747 Moxifloxacin Versus Amoxicillin Clavulanic Acid in Treatment of Acute Exacerbation of Chronic Bronchitis https://ClinicalTrials.gov/show/NCT00656747 Completed Bayer 2010-12-31
NCT00649831 A Multicentre, Randomised, Open-Label Study To Compare The Efficacy And Safety Of Azithromycin For 5 Days With Those Of Amoxicillin-Clavulanic Acid In Patients With Chronic Bronchitis https://ClinicalTrials.gov/show/NCT00649831 Completed Pfizer NA
NCT00645086 Comparative Study of 5 Days of M02-472 Clarithromycin Extended-Release Tablets to 7 Days of Clarithromycin Immediate-Release Tablets for the Treatment of Exacerbation of Chronic Bronchitis https://ClinicalTrials.gov/show/NCT00645086 Completed Abbott 2004-04-30
NCT00644449 A Multicenter, Randomized, Double-Blind, Double-Dummy Trial of Azithromycin SR Compared With Levofloxacin for the Treatment of Acute Symptoms of Chronic Bronchitis https://ClinicalTrials.gov/show/NCT00644449 Completed Pfizer NA
NCT00642447 Helium:Oxygen Noninvasive Positive Pressure Ventilation in Patients Exposed to Sulfur Mustard https://ClinicalTrials.gov/show/NCT00642447 Completed Baqiyatallah Medical Sciences University NA
NCT00546676 Ketek in CAP / AECB in Ambulatory Adult Patients https://ClinicalTrials.gov/show/NCT00546676 Completed Sanofi NA
NCT00538148 Telithromycin: in the Treatment of Acute Exacerbation of Chronic Bronchitis in Adult Outpatients With COPD https://ClinicalTrials.gov/show/NCT00538148 Completed Sanofi 2004-09-30
NCT00483743 Safety, Tolerability and PD Activity of Inhaled TPI 1020 Versus Inhaled Budesonide in COPD Patients https://ClinicalTrials.gov/show/NCT00483743 Completed Pharmaxis 2008-12-31
NCT00473460 Intermittent Moxifloxacin Therapy For The Prevention Of Acute Exacerbations In Patients With Chronic Bronchitis https://ClinicalTrials.gov/show/NCT00473460 Completed Bayer 2007-01-31
NCT00441246 Phase 4 Study - Mucinex D as Adjunct Therapy https://ClinicalTrials.gov/show/NCT00441246 Completed Adams Respiratory Therapeutics 2007-05-31
NCT00424528 Efficacy Safety Study of Arformoterol/Tiotropium Combination Versus Either Therapy Alone in Chronic Obstructive Pulmonary Disease (COPD) https://ClinicalTrials.gov/show/NCT00424528 Completed Sunovion 2007-10-31
NCT00423137 Effect of BIBW 2948 BS in COPD https://ClinicalTrials.gov/show/NCT00423137 Completed Boehringer Ingelheim 2008-07-31
NCT00415753 Procalcitonin as a Marker of Bacterial Pneumonia https://ClinicalTrials.gov/show/NCT00415753 Completed Aarhus University Hospital Skejby 2007-04-30
NCT00406705 The Effect of Breathing Helium-Hyperoxia During Pulmonary Rehabilitation in Patients With COPD https://ClinicalTrials.gov/show/NCT00406705 Completed University of Alberta NA
NCT00373932 Real-Time Support for Exercise Persistence in COPD https://ClinicalTrials.gov/show/NCT00373932 Completed University of Washington 2008-12-31
NCT00371527 Effect of Ipratropium on Acute Bronchitis in Subjects Without Underlying Lung Disease https://ClinicalTrials.gov/show/NCT00371527 Completed Kaiser Permanente NA
NCT00360464 A Trial Of Azithromycin SR For The Treatment Of Acute Bronchitis And Secondary Infection Of Chronic Respiratory Diseases https://ClinicalTrials.gov/show/NCT00360464 Completed Pfizer 2007-06-30
NCT00350987 Procalcitonin Guided Antibiotic Therapy and Hospitalisation in Patients With Lower Respiratory Tract Infections: The “ProHOSP” Study https://ClinicalTrials.gov/show/NCT00350987 Completed University Hospital, Basel, Switzerland 2008-06-30
NCT00338507 Phase 2 Study - Erdosteine in Patients With CB/COPD https://ClinicalTrials.gov/show/NCT00338507 Completed Adams Respiratory Therapeutics NA
NCT00269932 A Study of the Safety and Effectiveness of Oral Levofloxacin Compared With Cefuroxime Axetil in the Treatment of Adults With Persistent Bronchitis Experiencing Rapid Onset of Severe Worsening of Symptoms Caused by Bacteria https://ClinicalTrials.gov/show/NCT00269932 Completed Johnson & Johnson Pharmaceutical Research & Development, L.L.C. NA
NCT00269126 Clinical Evaluation Of GW815SF For Chronic Obstructive Pulmonary Disease (Chronic Bronchitis, Emphysema) https://ClinicalTrials.gov/show/NCT00269126 Completed GlaxoSmithKline 2005-08-31
NCT00269087 GW815SF For Chronic Obstructive Pulmonary Disease (Chronic Bronchitis, Emphysema) https://ClinicalTrials.gov/show/NCT00269087 Completed GlaxoSmithKline 2006-10-01
NCT00257140 A Study of the Safety and Effectiveness of Levofloxacin Compared With Cefaclor in the Treatment of Adults With Chronic Bronchitis Experiencing Rapid Onset of Worsening of Symptoms Caused by Bacteria https://ClinicalTrials.gov/show/NCT00257140 Completed Johnson & Johnson Pharmaceutical Research & Development, L.L.C. NA
NCT00254566 A Trial To Evaluate Two Antibiotics For The Treatment Of Acute Exacerbation Of Chronic Bronchitis (AECB) https://ClinicalTrials.gov/show/NCT00254566 Completed Pfizer 2008-08-31
NCT00250679 Safety and Efficacy of Arformoterol Tartrate Inhalation Solution in Subjects With Chronic Obstructive Pulmonary Disease https://ClinicalTrials.gov/show/NCT00250679 Completed Sunovion 2007-10-31
NCT00245427 Outcomes of Patients Not Responding to Antibiotics in the Community https://ClinicalTrials.gov/show/NCT00245427 Completed CPL Associates NA
NCT00205647 Study of Expectorant Activity of Oral N-acetylcystein (NAC) in Patients With Stable Chronic Bronchitis https://ClinicalTrials.gov/show/NCT00205647 Completed Wake Forest University Health Sciences NA
NCT00184977 COPD on Primary Care Treatment (COOPT) https://ClinicalTrials.gov/show/NCT00184977 Completed Radboud University NA
NCT00181207 Airway Clearance for Prevention of Chronic Obstructive Pulmonary Disease (COPD) Exacerbation https://ClinicalTrials.gov/show/NCT00181207 Completed Johns Hopkins University 2007-11-30
NCT00175565 Inhaled Steroid Reduces Systemic Inflammation in COPD https://ClinicalTrials.gov/show/NCT00175565 Completed University of British Columbia NA
NCT00153634 Standard vs. Biofilm Susceptibility Testing in Cystic Fibrosis (CF) https://ClinicalTrials.gov/show/NCT00153634 Completed Seattle Children’s Hospital NA
NCT00132938 PERSPECTIVE: Telithromycin - Acute Exacerbation of Chronic Bronchitis https://ClinicalTrials.gov/show/NCT00132938 Completed Sanofi 2006-05-31
NCT00106080 Improving the Quality of End-of-Life Communication for Patients With Chronic Obstructive Pulmonary Disease (COPD) https://ClinicalTrials.gov/show/NCT00106080 Completed VA Office of Research and Development 2008-05-31
NCT00064415 To Evaluate the Long-term Safety of (R,R)-Formoterol in Subjects With COPD https://ClinicalTrials.gov/show/NCT00064415 Completed Sunovion 2004-12-31
NCT00064402 Determine the Safety and Efficacy of (R,R)-Formoterol in the Treatment of Subjects With COPD https://ClinicalTrials.gov/show/NCT00064402 Completed Sunovion 2004-03-31
NCT00051792 Yoga for Treating Shortness of Breath in Chronic Obstructive Pulmonary Disease (COPD) https://ClinicalTrials.gov/show/NCT00051792 Completed National Center for Complementary and Integrative Health (NCCIH) NA
NCT00042718 A Study of the Effectiveness and Safety of High Dose, Short-course Levofloxacin in the Treatment of Acute Bacterial Exacerbation (Worsening) of Chronic Bronchitis. https://ClinicalTrials.gov/show/NCT00042718 Completed Johnson & Johnson Pharmaceutical Research & Development, L.L.C. NA
NCT00035828 A Blinded Study Comparing the Safety and Efficacy of a Fully Human Anti-IL8 Monoclonal Antibody (ABX-IL8) to Placebo in Patients With Chronic Bronchitis and COPD https://ClinicalTrials.gov/show/NCT00035828 Completed Abgenix NA

Observational Studiess

#If less then 500 studies

nct_id brief_title link overall_status source primary_completion_date
NCT03320382 Multiple Breath Washout, a Clinimetric Dataset https://ClinicalTrials.gov/show/NCT03320382 Recruiting Imperial College London 2021-03-31
NCT03049202 BROnchoalveolar Investigations of Never-smokers With Chronic Obstruction From the Swedish CardioPulmonary bioImage Study https://ClinicalTrials.gov/show/NCT03049202 Recruiting Karolinska Institutet 2020-06-01
NCT03011515 Evaluating a Host-response Based Diagnostic for Distinguishing Between Bacterial and Viral Etiology in Patients With Lower Respiratory Tract Infection (LRTI) https://ClinicalTrials.gov/show/NCT03011515 Active, not recruiting MeMed Diagnostics Ltd. 2019-05-01
NCT03010592 Studying the Airway Microenvironment in Patients Undergoing Surgical and Bronchoscopic Interventions for COPD https://ClinicalTrials.gov/show/NCT03010592 Recruiting Royal Brompton & Harefield NHS Foundation Trust 2020-01-31
NCT02902640 A Non-Interventional Safety Study of Balsamic Bactrim https://ClinicalTrials.gov/show/NCT02902640 Completed Hoffmann-La Roche 2017-07-31
NCT02879981 A Safety Study of Balsamic Bactrim in Pediatric Participants With Acute Bronchitis https://ClinicalTrials.gov/show/NCT02879981 Completed Hoffmann-La Roche 2017-08-28
NCT02637219 Innate Immune Response in COPD https://ClinicalTrials.gov/show/NCT02637219 Completed VA Puget Sound Health Care System 2008-01-31
NCT02632851 Treatment of Respiratory Tract Infection and/or Acute Bronchitis With Ectoin Inhalation Solution https://ClinicalTrials.gov/show/NCT02632851 Completed Bitop AG 2016-05-31
NCT02627872 Clinical & Systems Medicine Investigations of Smoking-related Chronic Obstructive Pulmonary Disease https://ClinicalTrials.gov/show/NCT02627872 Active, not recruiting Karolinska Institutet 2020-12-31
NCT04144699 Clinical Validation of Omron WheezeScan https://ClinicalTrials.gov/show/NCT04144699 Recruiting Omron Healthcare Co., Ltd. 2020-02-28
NCT02233920 Post-marketing Surveillance of Ventilat® Metered Dose Inhaler in Chronic Obstructive Bronchitis https://ClinicalTrials.gov/show/NCT02233920 Completed Boehringer Ingelheim 2000-12-31
NCT02128529 Epidemiology of Chronic Bronchitis in Patients With Chronic Obstructive Pulmonary Disease (COPD) https://ClinicalTrials.gov/show/NCT02128529 Completed AstraZeneca 2011-04-30
NCT01302587 A Study to Evaluate the Integrated Dose Counter on an Albuterol Hydrofluoroalkane (HFA) Metered Dose Inhaler (MDI) https://ClinicalTrials.gov/show/NCT01302587 Completed Teva Pharmaceutical Industries 2011-06-30
NCT01969344 Study of COPD Subgroups and Biomarkers https://ClinicalTrials.gov/show/NCT01969344 Active, not recruiting University of North Carolina, Chapel Hill 2022-05-31
NCT01787227 A Two Arm, Multi-Centre Clinical Evaluation of the NxTAG Respiratory Pathogen Panel https://ClinicalTrials.gov/show/NCT01787227 Completed Luminex Molecular Diagnostics 2015-09-30
NCT01563757 Plastic Bronchitis and Protein Losing Enteropathy in Children With Single Ventricle Physiology https://ClinicalTrials.gov/show/NCT01563757 Completed Medical College of Wisconsin 2013-09-30
NCT01515709 Is the Short Physical Performance Battery a Useful Outcome Measure in Chronic Obstructive Pulmonary Disease https://ClinicalTrials.gov/show/NCT01515709 Completed Royal Brompton & Harefield NHS Foundation Trust 2013-09-30
NCT01507415 Do the SPPB and 4-metre Gait Speed Predict Hospital Readmission in Patients Hospitalised for Acute Exacerbation if COPD? https://ClinicalTrials.gov/show/NCT01507415 Completed Royal Brompton & Harefield NHS Foundation Trust 2013-02-28
NCT01476995 Prognostic Indicators as Provided by the EPIC ClearView https://ClinicalTrials.gov/show/NCT01476995 Completed Epic Research & Diagnostics, Inc. 2011-06-30
NCT01354938 Outcome Study to Evaluate Klaricid XL® (Clarithromycin Modified Release) in Patients With Acute Exacerbation of Chronic Bronchitis https://ClinicalTrials.gov/show/NCT01354938 Completed Abbott 2012-01-31
NCT03657121 Mortality and Symptom Burden Post Hospitalisation With COPD https://ClinicalTrials.gov/show/NCT03657121 Active, not recruiting Northumbria Healthcare NHS Foundation Trust 2020-08-31
NCT03535558 Fluoroquinolone Associated Disability https://ClinicalTrials.gov/show/NCT03535558 Completed Janssen Research & Development, LLC 2018-12-31
NCT01156701 Prophylactic Efficacy of Relenza Against Influenza A and B https://ClinicalTrials.gov/show/NCT01156701 Completed GlaxoSmithKline 2010-05-31
NCT01130883 Evaluation of Effectiveness of the Treatment After Repeated Administration of Klacid®SR https://ClinicalTrials.gov/show/NCT01130883 Completed Abbott 2010-07-31
NCT01108185 Evaluation of the Treatment With Klacid®SR in Patients With Lower Respiratory Tract Infection https://ClinicalTrials.gov/show/NCT01108185 Completed Abbott 2010-07-31
NCT01095978 Evaluation of the Treatment With Klacid SR in Patients With Acute Tracheitis, Tracheobronchitis and Bronchitis, Acute Exacerbation of Chronic Bronchitis and Mild Community-acquired Pneumonia in Common Clinical Practice in Ukraine https://ClinicalTrials.gov/show/NCT01095978 Completed Abbott 2010-05-31
NCT00932802 Greatest International Antiinfective Trial With Avelox https://ClinicalTrials.gov/show/NCT00932802 Completed Bayer 2007-11-30
NCT00903955 Mucus Dehydration and Evolution of Chronic Obstructive Pulmonary Disease (COPD) Lung Disease https://ClinicalTrials.gov/show/NCT00903955 Completed University of North Carolina, Chapel Hill 2012-03-31
NCT00879008 SYMPROVE III: Health Services Research Study for Treatment of the Moderate and Severe Acute Exacerbations of Chronic Bronchitis (AECB) https://ClinicalTrials.gov/show/NCT00879008 Completed Bayer 2010-08-31
NCT00876577 VICTOR - Avelox® Intravenous (i.v.) in Acute Exacerbations of Chronic Bronchitis https://ClinicalTrials.gov/show/NCT00876577 Completed Bayer 2011-03-31
NCT00871637 Airway Macrophages and Sputum Milieu in Adult Subjects With Airflow Obstruction https://ClinicalTrials.gov/show/NCT00871637 Completed University of Nebraska 2009-06-30
NCT00846911 AVANTI - Avelox® in Acute Exacerbations of chroNic bronchiTIs https://ClinicalTrials.gov/show/NCT00846911 Completed Bayer 2010-04-30
NCT04163653 Lymphatic Morphology of Fontan Patients https://ClinicalTrials.gov/show/NCT04163653 Active, not recruiting University of Aarhus 2020-01-01
NCT00974064 The Natural History of Gene Expression in the Lung Cells of Non-Smokers, Smokers and Ex-Smokers in Health and Disease https://ClinicalTrials.gov/show/NCT00974064 Active, not recruiting Weill Medical College of Cornell University 2020-03-31
NCT00729131 Functional Implications of TNF https://ClinicalTrials.gov/show/NCT00729131 Completed National Institute of Environmental Health Sciences (NIEHS) 2010-01-31
NCT00608764 Examining the Genetic Factors That May Cause Chronic Obstructive Pulmonary Disease (COPD) https://ClinicalTrials.gov/show/NCT00608764 Active, not recruiting Brigham and Women’s Hospital 2022-12-31
NCT00454675 Pulmonary Function Changes in 10 Pack Year Smokers With Chronic Bronchitis https://ClinicalTrials.gov/show/NCT00454675 Completed Westside Family Medical Center, P.C. NA
NCT00442468 Airway Limitation Study: Study In Primary Care Centers Of Chronic Bronchitis In Long-Term Cigarette Smokers Of At Least 40 Years Of Age With Symptoms Of Cough And Shortness Of Breath https://ClinicalTrials.gov/show/NCT00442468 Completed GlaxoSmithKline 2007-09-30
NCT00342030 Dietary and Genetic Factors in Asthma & Chronic Bronchitis in a Cohort of Chinese Singaporeans https://ClinicalTrials.gov/show/NCT00342030 Completed National Institutes of Health Clinical Center (CC) NA
NCT00298389 Macrophage Phagocytosis in COPD https://ClinicalTrials.gov/show/NCT00298389 Completed Imperial College London 2010-12-31
NCT00224198 Evaluation of the Lungs of Individuals With Lung Disease https://ClinicalTrials.gov/show/NCT00224198 Completed Weill Medical College of Cornell University 2012-09-30
NCT00147017 Regulation of the Release of Inflammatory Mediators From Lung Macrophages. https://ClinicalTrials.gov/show/NCT00147017 Completed Imperial College London 2010-12-31
NCT00147082 Leukocyte Function in Chronic Obstructive Pulmonary Disease (COPD) https://ClinicalTrials.gov/show/NCT00147082 Completed Imperial College London 2004-12-31
NCT00147069 Leukocyte Function in Asthma and COPD https://ClinicalTrials.gov/show/NCT00147069 Completed Imperial College London 2007-04-30
NCT00005123 Honolulu Heart Program https://ClinicalTrials.gov/show/NCT00005123 Completed National Heart, Lung, and Blood Institute (NHLBI) NA
NCT00011310 Cardiopulmonary Effects of Particulate Exposure https://ClinicalTrials.gov/show/NCT00011310 Completed National Institute of Environmental Health Sciences (NIEHS) NA
NCT00005298 Inflammation, Autonomic Dysfunction and Airway Disease https://ClinicalTrials.gov/show/NCT00005298 Completed National Heart, Lung, and Blood Institute (NHLBI) NA
NCT00005279 Tucson Epidemiology Study of Chronic Obstructive Lung Diseases https://ClinicalTrials.gov/show/NCT00005279 Completed National Heart, Lung, and Blood Institute (NHLBI) NA
NCT00005717 Medication Adherence in COPD–A Self-Regulation Study https://ClinicalTrials.gov/show/NCT00005717 Completed National Heart, Lung, and Blood Institute (NHLBI) NA

Registries

#If less then 500 registries

nct_id brief_title link overall_status source primary_completion_date
NCT02803242 COPD Patient-Powered Research Network https://ClinicalTrials.gov/show/NCT02803242 Recruiting COPD Foundation 2025-01-31
NCT02164968 Assessment of Respiratory Symptoms After Corticosteroid Treatment Period Using Impedance Pneumography https://ClinicalTrials.gov/show/NCT02164968 Completed Tampere University Hospital 2017-11-30
NCT02045394 Epidemiology and Diagnosis of Haemoptysis: a Multicenter Study https://ClinicalTrials.gov/show/NCT02045394 Completed University of Milan 2015-10-31
NCT00307281 Emphysema/COPD Research Registry https://ClinicalTrials.gov/show/NCT00307281 Recruiting University of Pittsburgh 2030-07-31